Lysergic acid diethylamide

LSD, LSD-25

Salts []
Lysergic acid diethylamide maleate

Lysergic acid diethylamide tartrate

Molecular structure via molpic based on CDK

Rotamer []

Conformer structure via 3Dmol.js

Physical properties []
Molecular mass	323.4 g/mol ^[1]
Appearance	Pointed prisms from benzene ^[1]
Odor	Odorless ^[1]
Taste	Tasteless ^[1]
Melting point	176 to 185 °F (NTP, 1992) ^[1]
Decomposition	When heated to decomposition it emits toxic fumes of /nitrogen oxides/. ^[1]
Solubility	Water soluble ^[1]
Predicted LogP	3 ^[1]

Structural Identifiers []
Molecular formula	C₂₀H₂₅N₃O ^[1]
IUPAC name	(6aR,9R)-N,N-diethyl-7-methyl-6,6a,8,9-tetrahydro-4H-indolo[4,3-fg]quinoline-9-carboxamide ^[1]
SMILES	CCN(CC)C(=O)[C@H]1CN([C@@H]2CC3=CNC4=CC=CC(=C34)C2=C1)C ^[1]
InChI	InChI=1S/C20H25N3O/c1-4-23(5-2)20(24)14-9-16-15-7-6-8-17-19(15)13(11-21-17)10-18(16)22(3)12-14/h6-9,11,14,18,21H,4-5,10,12H2,1-3H3/t14-,18-/m1/s1 ^[1]
InChIKey	VAYOSLLFUXYJDT-RDTXWAMCSA-N ^[1]

Pharmacokinetics[]
Elimination half-life	3.6 hours
Duration of action	Oral administration\|Oral: 7 – 12 (range 4 – 22) hoursIntramuscular injection, Intravenous injection, Intrathecal injection: 8 – 10 hours

Toxicity []
TD_Lo	Human: - oral: 700 ng/kg - oral: 2857 ng/kg - intramuscular: 750 ng/kg - oral: 857 ng/kg
LD₅₀	Rat: - intravenous: 16 mg/kg Mouse: - intraperitoneal: 50 mg/kg - intravenous: 46 mg/kg Rabbit: - intravenous: 300 μg/kg Guinea pig: - subcutaneous: 16 mg/kg Bird - wild: - oral: 1800 μg/kg

Dosing[]

Sublingual []
Light	≤ 0.2 mg
Common	0.2 - 0.3 mg
Strong	0.3 mg
Heavy	0.3 - 0.5 mg
Extreme	0.5 mg +

Oral []
Light	≤ 0.2 mg
Common	0.2 - 0.3 mg
Strong	0.3 - 0.6 mg
Heavy	0.6 - 0.8 mg
Extreme	0.8 mg +

Statistically derived dosages via DBI-IGS

We do not take any responsibility for medical complications or loss of life sustained by following these dosages blindly.

Lysergic acid diethylamide (also known as Lysergide, Lsd, N,N-Diethyllysergamide, Lysergsaeurediaethylamid, N,N-Diethyl-D-lysergamide, Lysergaure diethylamid, LSD-25, LSD 25, Lisergide or Lysergidum) is a psychedelic substance of the lysergamide class.

Chemistry

Pharmacology

ATC Classification

Metabolism

Subjective effects []

Usernotes []
x86pup / Lysergic acid diethylamide via Oral, Sublingual	-
magnus / Lysergic acid diethylamide via Oral	-
0xea / Lysergic acid diethylamide via Oralat 150mcg oral	made me more concious of how dissociation influences my perception of reality; broke communication down to a fluid simplified interface; vulnerable animalistic perception of organic living beings; enabled understanding repressed part of myself

Legal status []

Australia: Lysergic acid diethylamide is a Schedule 9 substance.
Brazil: Lysergic acid diethylamide is a F2 substance.
Canada: Lysergic acid diethylamide is a Schedule III substance.
New Zealand: Lysergic acid diethylamide is a Class A substance.
United Kingdom: Lysergic acid diethylamide is a Class A substance.
United Nations: Lysergic acid diethylamide is a Schedule I drug under the "Convention on Psychotropic Substances 1971".
United States: Lysergic acid diethylamide is a Schedule I under the "Controlled Substances Act (CSA)".
Germany: Lysergic acid diethylamide is a Anlage I substance.

References []

National Center for Biotechnology Information. PubChem Compound Summary for CID 5761, Lysergic acid diethylamide. Accessed October 13, 2025. https://pubchem.ncbi.nlm.nih.gov/compound/5761
U.S. Food and Drug Administration; National Center for Advancing Translational Sciences. Lysergic acid diethylamide. UNII: 8NA5SWF92O. Global Substance Registration System. Accessed October 13, 2025. https://gsrs.ncats.nih.gov/ginas/app/beta/substances/8NA5SWF92O

Anodyne

Lysergic acid diethylamide

Chemistry

Salts []

Stereochemistry []